Endocrine Abstracts

Objectives: The aim of the study was to evaluate the normal reference values for thyroid uptake using Technetium-99 m (Tc-99 m) pertechnetate.Methods: Sixty-seven euthyroid patients with primary hyperparathydism who underwent parathyroid imaging with Tc-99 m pertechnetate between January 2012 to April 2014 at the Nuclear Medicine department, Newcastle upon Tyne Hospitals was studied. Electronic medical records and biochemical thyroid functi...

Introduction: With a prevalence of about one in 3000 newborns, congenital hypothyroidism (CH) is the leading cause of preventable mental retardation and growth failure. The objective of this work is to clarify the contribution of thyroid scintigraphy (TS) using technetium 99 m for the diagnosis of CH and this through the experience of the nuclear medicine department in Sahloul university Hospital.Materials and methods: This is a retrospective study inclu...

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Although the cause of the anovulation is unknown there are a number of endocrine candidates; hyperinsulinaemia, raised steroid production and increased levels of the sexual differentiative factor anti-Müllerian hormone (AMH). The latter is increasingly thought to be an inhibitor of folliculogenesis. Hyperinsulinaemia in PCOS is now widely treated with metformin and we have shown that thi...

IntroductionDapagliflozin is sub-optimally utilised in the real world. There is a lack of a comprehensive collaborative guidance for a practical approach to manage patients with cardiometabolic, renometabolic and viscerometabolic disorders. Patients across the CRV-M continuum includes patients with varied clinical profiles.MethodsTwo round Delphi study was conducted using a virtual online-digital connect appr...

Introduction: Adequate iodine intake is important in pregnant women.Objective: To determinate iodine status and thyroid volumen (TV) in healthy pregnant women from Navarra (Spain), and to evaluate possible influence of diet.Methods: A cross-sectional study of 144 women in the first trimester of pregnancy (single pregnancies) was carried during 2014. We measured thyroid-stimulating hormone (TSH), free thyroxine (fT4) and antithyroid...

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

AMH causes regression of Müllerian ducts during male fetal development. Recently, AMH was detected in the adult ovary, principally in granulosa cells (GCs). Studies have demonstrated a 1.5–5 fold increase in serum AMH in women with PCOS compared to normal ovulatory women. The AMH rise was assumed to be secondary to increased numbers of follicles. Interestingly, the insulin sensitiser metformin, which is in widespread use in PCOS, caused a significant reduction in ser...

Introduction: Obesity is one of the most important problems worldwide in recent times. Groupal lifestyle intervention programmes are efficacious in the management of obesity. While exercise and healthy dietary habits have consistently been shown to improve various metabolic markers, adherence to these behaviors is low and methods that increase adherence to health behaviors are needed.Objective: The primary objective of this study is to evaluate the effec...

Introduction: Primary thyroid lymphomas (PTL) account for 5% of all thyroid malignancies. Treatment and prognosis depend on tumor subtype. Contrasting with diffuse large B-cell lymphomas (DLBCL), that have an aggressive clinical course and higher maximum standardized uptake value (SUVmax) in Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET), thyroid extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) usually show an indolen...

Evidence on whether neonatal thyroid screening results are dependent on maternal thyroid function is limited.Objectives: To study the relationship between iodine status and maternal thyroid function in pregnancy, and neonatal screening results in a Northern Spanish population.Methods: Prospective, longitudinal study of 297 pregnant women recruited in 2 obstetric centers of Pamplona (Spain) at the first antenatal visit, and their ne...